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Nature conducted a survey in 2016 with 1,576 researchers, and 52% of participants agreed on the existence of a “reproducibility crisis”. Disappointing results were gained from replication efforts on selected high-profile papers in cancer biology. Nevertheless, the scientific community discovered a few key factors that influence reproducibility, including inappropriate study design, improper statistics, lack of data sharing and data transparency, undocumented subtle protocol details, different or mislabeled reagents, and poorly reproducible measurement methods.
In 2019, the PI’s lab led a cross-lab study reporting the multi-omic heterogeneity in HeLa cells, which was published in Nature Biotechnology. This study and many others indicate that the complexity inherent in biological systems further challenges the reproducibility of life science research. We hope to make use of the Online Forum feature in our Lab Webpage to engage more scientists and visitors to continue the discussion of key elements that influence research reproducibility. All visitors to the Forum can sign in with their email or Google and Facebook accounts and share their opinions, knowledge, research stories, and video links about the topic of research producibility – especially in the field of quantitative proteomics.